Many diseases can damage the nephrons because of which the kidneys lose their filtering capacity. It leads to high concentrations of waste products and chemicals in the body that may eventually become life-threatening. When the kidneys lose around 90% of their filtering ability, the individual is said to have end-stage kidney disease. Diabetes is the most common cause of kidney failure in most parts of the world. High level of blood sugar over many years, slowly damages the filters in the kidneys. What results is chronic kidney disease (called diabetic nephropathy) that slowly progresses leading to end-stage kidney failure. The increase in blood pressure of the tiny blood vessels in the kidneys causes chronic irreversible damage leading to kidney disease.
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